Dopamine reduces slow outward current and calcium influx in burst- firing neuron R15 of Aplysia
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چکیده
منابع مشابه
Dopamine reduces slow outward current and calcium influx in burst-firing neuron R15 of Aplysia.
Dopamine's effect on calcium influx into the bursting neuron, R15, of Aplysia californica was tested by tail current measurements and by measurement of absorbance of intracellular Arsenazo III, a calcium-sensitive indicator. Slow outward tail currents were elicited by subthreshold depolarization in voltage clamp and were demonstrated to be dependent upon transient increases in intracellular cal...
متن کاملCalcium-dependent inactivation of a potassium current in the Aplysia neuron R15.
The endogenously bursting pacemaker neuron R15 of Aplysia exhibits an inwardly rectifying K+ current (IR) that was shown previously to be enhanced by various neurotransmitters via the intracellular second messenger, cyclic AMP (Drummond et al., 1980; Benson and Levitan, 1983; Levitan et al., 1987). Here we present evidence that Ca2+ influx, either caused by spontaneous bursting activity or elic...
متن کاملMechanism of calcium-dependent inactivation of a potassium current in Aplysia neuron R15: interaction between calcium and cyclic AMP.
In the preceding paper (Kramer and Levitan, 1988), we presented evidence that an inwardly rectifying K+ current (IR) is inactivated by Ca2+ influx accompanying spontaneous bursting activity in the Aplysia neuron R15. In this paper we examine the mechanism that enables Ca2+ to inactivate IR. Since IR is enhanced by cyclic AMP in neuron R15 (Drummond et al., 1980; Benson and Levitan, 1983), we ex...
متن کاملA cyclic GMP analog decreases the currents underlying bursting activity in the Aplysia neuron R15.
Bath application of 8-parachlorophenylthio-cyclic GMP (8-pcpt-cGMP) has been shown to increase the number of action potentials per burst in the Aplysia neuron R15. Here we report that 8-pcpt-cGMP can eventually inhibit R15's bursting activity and cause the cell to exhibit slow tonic spiking activity. This action is preceded by decreases in spike frequency and in the amplitude of the interburst ...
متن کاملDecreased Response to Acetylcholine during Aging of Aplysia Neuron R15
How aging affects the communication between neurons is poorly understood. To address this question, we have studied the electrophysiological properties of identified neuron R15 of the marine mollusk Aplysia californica. R15 is a bursting neuron in the abdominal ganglia of the central nervous system and is implicated in reproduction, water balance, and heart function. Exposure to acetylcholine (...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1984
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.04-12-03014.1984